Home – Migergot2021-07-20T12:33:26+00:00
  • Many migraine patients experience excessive nausea and vomiting during migraine attacks, making it difficult to take any oral medication. In these cases, taking a medicine rectally may be an effective way to get relief.
  • Migergot® is a medicine for migraine that utilizes this alternate delivery approach for preventing and treating migraines. The medication is administered rectally, which can be beneficial for patients suffering from migraines accompanied with nausea and vomiting symptoms.
  • Migergot® is indicated as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants or so-called “histaminic cephalalgia”.
  • Migergot® contains ergotamine tartrate and caffeine which are medicines that cause narrowing of the blood vessels in the brain.
  • Migergot® is only available in the United States with a prescription from a healthcare professional. Ask your provider if Migergot® is right for you.

What is the most important information I should know about Migergot®?

  • Serious and/or life-threatening reductions in blood flow to the brain or extremities have been reported due to interactions between the active ingredients in Migergot® (ergotamine tartrate and caffeine) and protease inhibitors and macrolide antibiotics. These medications should not be taken together.

What is Migergot®?

  • Migergot® is a prescription medicine used as a therapy to abort or prevent vascular headache, e.g., migraine, migraine variants or so-called “histaminic cephalalgia”.

Do not take Migergot® if you:

  • Are taking certain anti-HIV medications known as protease inhibitors such as ritonavir, nelfinavir or indinavir
  • Are taking a macrolide antibiotic such as erythromycin, clarithromycin or troleandomycin
  • Are taking antifungal medications such as ketoconazole or irtraconazole
  • Have high blood pressure or if you have any disease affecting your heart, arteries or blood circulation
  • Have liver or kidney disease
  • You are pregnant or may become pregnant
  • Are allergic to any of the ingredients in Migergot®

How to take Migergot® (Ergotamine Tartrate and Caffeine Suppository, USP):

  • Migergot® is a rectal suppository. Do not take Migergot® orally.
  • One suppository of Migergot® should be taken at the first sign of a migraine attack. If you do not experience relief from the first dose, a second dose may be taken no sooner than 60 minutes after the first dose.
  • The use of Migergot® should not exceed dosing guidelines and should not be used on a daily basis.
    • Do not take more than 2 suppositories for any single migraine attack.
    • Do not take more than 5 suppositories during any 7-day period.

Contact your doctor immediately if you experience:

  • Numbness or tingling in the fingers or toes
  • Muscle pain in the arms and legs
  • Weakness in the legs
  • Chest pain
  • Temporary speeding or slowing of the heart rate
  • Swelling or itching

Other side effects of Migergot® (Ergotamine Tartrate and Caffeine Suppository, USP) may include nausea and vomiting, rectal or anal ulcer (from overuse of suppositories), sensation of tingling or limbs “falling asleep”, numbness, weakness, dizziness, swelling and itching. This is not a complete list of all possible side effects. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. This is the most important information to know about Migergot®. Ask your healthcare professional if you have any questions or want more information.

Please see the Prescribing Information, including Boxed Warning, for more information.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.fda.gov/medwatch or call 1-800-FDA-1088.